What is Ultram? Ultram 50 mg  is a pain drug analogous to an opioid. It acts in the central nervous system( CNS) to relieve pain. Ultram is used to treat moderate to severe pain in grown ups. The extended- release form of tramadol( Ultram ER) is for around the timepiece treatment of pain. Ultram ER isn't for use on an as demanded base for pain....